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NP-NIBP MONITOR FOR MICE & RATS

NP-NIBP MONITOR FOR MICE & RATS

To measure blood pressure of small animals such as rats or mice using conventional BP Monitors, animals had to be preheated by some means. However, the advent of MK-2000 has made it possible to measure blood pressure without preheating animals provided that the room temperature is at least 23 degrees C. MK-2000ST is the successor to MK-2000 and has become more compact than ever before.

Description

Introducing the First and only Non-Preheating, Non-Invasive Blood Pressure Monitor for Mice and Rats in the world

Capable of recording from neonatal mice (1.4 g) to aged rats (1 kg)

Colored mice such as C57BL/6 can be mesured!

Introduction

To measure blood pressure of small animals such as rats or mice using conventional BP Monitors, animals had to be preheated by some means. However, the advent of MK-2000 has made it possible to measure blood pressure without preheating animals provided that the room temperature is at least 23 degrees C. MK-2000ST is the successor to MK-2000 and has become more compact than ever before.
MK-2000ST is ideal for investigating the effects of drugs on animals.  Once the animals are restrained properly, just press the START key and HR (Heart Rate), SBP (Systolic BP), MBP (Mean BP) and DBP (Diastolic BP, calculated value) will be automatically measured.

It photoplethysmographically measures pulsatile blood pressure of tail arteries. Pulses are stored into the computer memory and the peak levels of the pulses are plotted on the display. X-axis indicates cuff pressure, and Y-axis indicates amplitude of pulses. Using this method, the operator can decrease the risk of selecting artifacts and BP measurement is made more objective compared to the conventional digital display method.

SBP is initially estimated by inflating the cuff at approximately 25 mmHg/sec. During cuff deflation at about 4-5 mmHg/sec, SBP is determined precisely. SBP is defined as the point when the pulse reappears.

Main Features

  1. Two operation modes are available.
    With Mode 1 HR (Heart Rate) and SBP (Systolic Blood Pressure) are measured. With Mode 2 HR, SBP, MBP (Mean Blood Pressure) and DBP (Diastolic Blood Pressure, calculated value) can be measured.

    MODE1 HR SBP
    MODE2 HR SBP MBP (DBP)

    NOTE:HR (Heart Rate), SBP (Systolic BP), MBP (Mean BP), DBP (Diastolic BP, calculated value)

  2. Continuous Measurement Function
    Continuous measurement can be performed up to ten (10) times. Further, continuous & rapid measurement can also be performed in order to shorten the measuring time.
  3. Rapid Printout Function
    Onscreen data including average (AV) and standard deviation (SD), are printed out in about one (1) second by the high-performance thermal printer. Data may also be deleted at the operator’s discretion.
  4. Colored mice such as C57BL/6,  neonatal mice weighing 1.4 grams, hamsters (anaesthetized) and  guinea pigs (non-anaesthetized), of which blood pressure was so far considered difficult to measure, can be measured.
  5. Sick animals can be measured. (e.g.  animal with cardiac infarction)
  6. Multi-channel system is no longer needed. Just prepare multiple restrainers, and measurement can be done one after the other.
  7. Auto-Sequence Function
    Blood pressure of a tail artery of an animal can be monitored automatically at specified time intervals, which can be 1 – 99 minutes in length. At each interval, anywhere from 1-10 measurements can be made. This function invokes a series of procedures automatically— measurement,  printout of data and transfer to a PC.
  8. Time-Stamp Function
    The MK-2000ST precisely records the time of each BP measurement.
  9. Hard Copy Function
    The screen on the display can be captured to the thermal printer using the PrtScreen key.
  10. An RS-232C interface is provided on the rear panel of the main unit. Using the optional DCS-2000 Data Collection Software  (Windows Version) the data obtained can be exported to a personal computer and stored as a CSV file.
  11. The animal holders are made of dark brown acryl, allowing BP measurement under relatively stress-free conditions.
  12. Operation is very simple.

Specification

Specifications   Value

SBP

Cuff pressure when pulse reappears
MBPCuff pressure when pulse amplitude becomes largest
DBPCalculated value based on SBP and MBP (3MBP-SBP)/2
DetectionLED, Photo Transistor
Inflation Range0-350 mmHg
Printer OutputsDate, Time, Animal No., Weight, Operation Mode, Interval, No of Measuring Trials, Raw Data, Average and S.D.
Chart PaperThermo-sensitive 58 mm Wide x 25 m Long
PowerPlease specify your input voltage when ordering.
DimensionsW210 x D310 x H210 mm
WeightApprox. 8 kg

 

Keyboard

Specifications   Value

Function Keys

33

Dimensions

W145 x D120 x H20 mm

Weight

Approx. 0.4 kg

The Standard System Comes Supplied with:

• Main Unit (Printer included) – 1
• Keyboard – 1
• Animal Holder (Any one from the list) – 1
• Cuff-pulse Sensor (Any one from the list) – 1
• Measuring Stand for Rats – 1
• TSP-10 Chart Paper (Pack of 5 Rolls) – 1
• APC-2000 Accessory Case – 1
• Dust Cover – 1
• Data Collection Software DCS-2000ST – 1

Animal Holders

Specifications Value
Mouse Holder (3S)5-10 g
Mouse Holder (SS)10-20 g
Mouse Holder (S)20 – 30 g
Mouse Holder (M)30 – 40 g
Mouse Holder (L)40 – 50 g
Rat Holder (3S)50 – 70 g
Rat Holder (SS)70 – 90 g
Rat Holder (S)90 – 150 g
Rat Holder (SM)150 – 210 g
Rat Holder (M)210 – 270 g
Rat Holder (ML)270 – 350 g
Rat Holder (L)350 – 500 g
Rat Holder (LL)500 – 800 g

 

Cuff-Pulse Sensors

Specifications Value
Neo24NH1.4-2 g
Neo32NH2-5 g
Neo40NH5-10 g
Mouse NH20-50 g
OB Mouse NHOB Mouse & Mouse 5 – 20 g
C57 Mouse NHC57BL6 Mouse
Hamster (S)NHApprox. 60 – 80 g
Hamster (M)NHApprox. 80 – 120 g
Hamster (L)NHApprox. 120 – 160 g
Rat (S)NH90 – 210 g
Rat (M)NH210 – 350 g
Rat (ML)NH350 – 500 g
Rat (L)NH500 – 800 g

 

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    Animal used : SHR
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    Animal used : SHR and Wky Rat
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    2)Graduate School of Medicine, NagoyaUniversity,65 Tsurumai-cho, Showa-ku,Nagoya 466-8550,Japan
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    5 Discovery Research Laboratory, Tanabe Seiyaku Co., Osaka, Japan
    Animal used : C57BL6 Mouse
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    Animal used : ddY Mouse
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    * From the Department of Anesthesiology, and the Surgical Operating Center, Wakayama Medical University, Wakayama City, Japan.
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    Kimiyasu Egami, MD; Satoshi Shintani, MD; Yosuke Katsuda, MD; Hisao Ikeda, MD;
    Yo-ichi Nabeshima, MD; Tsutomu Imaizumi, MD
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  12. Effects of Captoprill on Cardiac and Renal Damage, and Metabolic Alterations in the Nitric Oxide-Deficient Hypertensive Rat (Kidney Blood Pressure Research 2005; 28: 243-250)
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    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh , Saudi Arabia
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    Tomoji Mashimo, Birger Voigt, Takashi Kuramoto, and Tadao Serikawa
    Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  14. An X-Ray Diffraction Study on Mouse Cardiac Cross-Bridge Function In Vivo: Effects of Adrenergic ß-Stimulation (Biophysical Journal 90:1723-1728 (2006)
    Ryuji Toh,* Masakazu Shinohara,* Tomofumi Takaya,* Tomoya Yamashita,* Shigeru Masuda,*
    Seinosuke Kawashima,* Mitsuhiro Yokoyama,* and Naoto Yagiy
    *Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine,Kobe 650-0017, Japan; and ySPring-8/JASRI, Sayo, Hyogo 679-5198, Japan
  15. Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice (Am J Physiol Lung Cell Mol Physiol 290: L59-L65, 2006.)
    Shinsuke Murakami,1,2 Noritoshi Nagaya,1,3 Takefumi Itoh,2 Masaharu Kataoka,1 Takashi Iwase,1
    Takeshi Horio,3 Yoshinori Miyahara,4 Yoshiki Sakai,5 Kenji Kangawa,6 and Hiroshi Kimura2
    1Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research
    Institute, Osaka; 2Second Department of Internal Medicine, Nara Medical University, Nara; 3Department of
    Internal Medicine, National Cardiovascular Center, Osaka; 4Department of Cardiac Physiology, National
    Cardiovascular Center Research Institute, Osaka; 5Ono Pharmaceutical Co., Ltd. Research Headquarters,
    Osaka; and 6Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
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    Nai-Yuan Leea, Juei-Tang Chengb, Toshiki Enomotoc, Ichiro Nakamurad,
    a Livestock Research Institute, Tainan 712, Taiwan, R.O.C.
    b Department Pharmacology, College of Medicine, National Cheng Kung University,
    Tainan 70101, Taiwan, R.O.C.
    c Department of Food Science, Ishikawa Prefectural University, Nonoichi, Ishikawa 9218836, Japan
    d Institute of Animal Experimentation, School of Medicine, Hokkaido University, Sapporo 0608589, Japan
    Animal used : SHR
  17. Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats (Biol. Pharm. Bull. 29(8) 1756-1758 (2006) Vol. 29, No. 8
    KUBOTA Yoko1 UMEGAKI Keizo2 KAGOTA Satomi 3 TANAKA Naoko 4 NAKAMURA Kazuki 5 KUNITOMO Masaru 6 SHINOZUKA Kazumasa 7
    1 Department of Biopharmaceutics, Nihon Pharmaceutical University
    2 National Institute of Health and Nutrition
    3 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women’s University
    4 Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
    5 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women’s University
    6 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women’s University
    7 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women’s University
  18. Mechanical ventilation with 40% oxygen reduces pulmonary expressionof genes that regulate lung development and impairs alveolar septation in newborn mice
    (Am J Physiol Lung Cell Mol Physiol 293:1099-1110, 2007. )
    Richard D. Bland, Lucia M. Mokres, Robert Ertsey, Berit E. Jacobson, Shu Jiang, Marlene Rabinovitch,
    Liwen Xu, Eric S. Shinwell, Feijie Zhang, and Matthew A. Beasley
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California
  19. Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice.
    (Am J Physiol Lung Cell Mol Physiol 294:L3-L14, 2008. )
    Richard D. Bland, Robert Ertsey, Lucia M. Mokres, Liwen Xu, Berit E. Jacobson, Shu Jiang,
    Cristina M. Alvira, Marlene Rabinovitch, Eric S. Shinwell, and Anjali Dixit
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California

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