MK-800 E.C. Stimulator has been developed for the screening of anti-convulsant drugs. MK-800 has an unique “Step-up Mode” in addition to the conventional “Constant-current Mode”. Output current is controlled by the combination of analog feedback loop and microprocessor.
At the step-up mode, the output current is gradually stepped up at the user-defined rate, and the digital panel meter holds the current value delivered last.
The electroshock seizure threshold for each mouse can be determined by the test result. This method is useful for the assessment of both anti- and pro-convulsant activities of drugs (Y. Kitano et al: Journal of Pharmacological and Toxicological Methods Vol.35, Number 1, 1996)
Either constant-current or step-up mode can be selected at the operator’s discretion.
Corneal electrode is supplied with the instrument as a standard.